Platform Adventure Animals Wolves William and Sly Canines Thank you for rating the game You have already rated:) If you Like William and Sly 2, You May Also Want to Play These Adventure Games Hot Adventure Games Five Nights at Freddys Five Nights at Candys Pokemon Mega Adventure Time: Finn Bones Paper Minecraft Mao Mao: The Perfect Adventure New Adventure Games Mao Mao: The Perfect Adventure Kumus Adventure Cubic Castles Tiny Tomb: Dungeon Explorer Drake McDuck: Lost in Time Relics of the Fallen How to play William and Sly 2 Recommended video for you William and Sly 2 game comments Search English Contact Privacy About Joyland, All Rights Reserved Sitemap x.Molecular basis of human carbonic anhydrase II deficiency. Proc. Natl. Acad. Sci. U.S.A. 89 (5): 18048. Bibcode: 1992PNAS.89.1804R. doi: 10.1073pnas.89.5.1804. PMC 48541. PMID 1542674.Louis, Illinois, USA Nationality United States Alma mater St.
Louis University Known for Sly Syndrome Spouse(s) Margaret Ann Sly Children 7 Awards National Academy of Sciences Passano Foundation Award Peter H. Raven Lifetime Achievement Award Burlington Northern Foundation Faculty Achievement Award Coriell Medal in Scientific Achievement IBIS Marcel Simon Award Scientific career Fields Biochemistry Institutions St. He then joined the faculty at Washington University, where he directed the Division of Medical Genetics for 20 years. In February 2007, he was also named the inaugural holder of the James B. Joan C. Peters Endowed Chair in Biochemistry and Molecular Biology. His group described the first patient with MPS VII (Sly syndrome) and worked with collaborators at The Jackson Laboratory to develop and characterize the mouse model of this disease. He headed studies that identified the mannose-6 phosphate and mannose receptors that target enzymes to lysosomes, which provided the rationale for enzyme replacement therapy in Gauchers disease and other lysosomal storage diseases. These discoveries led to his election to the National Academy of Sciences in 1989. In recent years, he collaborated with Ulgtragenyx to develop enzyme replacement for MPS VII (Sly Syndrome) which is now in clinical trials. His laboratory has since characterized many other carbonic anhydrases and produced mouse models of several CA deficiencies. With collaborators, he identified other human diseases attributed to mutations in the genes encoding CA IV, CA VA, and CA XII. Dr. Sly has also done research on hereditary hemochromatosis, collaborating on studies leading to the cloning of the HFE gene and identification of the product it encodes. He also showed that the HFE gene knockout in the mouse produces iron storage resembling human hemochromatosis. He and his colleague James Shoemaker provided evidence that a woman convicted for poisoning her child with ethylene glycol (antifreeze) and sentenced to life in prison without parole, was wrongly convicted. Instead, her child had the inherited disease methylmalonic acidemia. An abnormally elevated metabolite called propionic acid in the childs serum had been misidentified as ethylene glycol. Dr. Sly has received many awards and honors for his research accomplishments, including induction into the National Academy of Sciences in 1989, the Coriell Medal from the Coriell Institute for Medical Research in Camden, New Jersey, for pioneering work in human genetics, the Peter H. Raven Lifetime Achievement Award from the Academy of Science of St. Louis, the Marcel Simon Prize from The Hemochromatosis Society in Albany, NY and the World Congress of Iron Metabolism in Cairns, Australia, the Distinguished Scientist Award from the Clinical Ligand Assay Society, the Passano Foundation Award (shared with Stuart Kornfeld), and the Burlington Northern Foundation Faculty Achievement Award for outstanding research. Dr. Sly has served on the Scientific Review Board and Medical Advisory Board for the Howard Hughes Medical Institute, the Board of Scientific Overseers for the Jackson Laboratory, and on many scientific societies and other foundations. He served on the editorial boards for several journals and was an editor for the classic metabolic text, The Metabolic and Molecular Bases of Inherited Diseases. Sly received an honorary doctor of science degree from Washington University in St. Human carbonic anhydrases and carbonic anhydrase deficiencies. PMID 7574487. Molecular basis of human carbonic anhydrase II deficiency. Proc. Natl. Acad. Sci. U.S.A. 89 (5): 18048. Bibcode: 1992PNAS.89.1804R. PMC 48541. PMID 1542674.
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